Derk is a Dutch masculine given name. Notable people with the name include:
Derk Bodde (1909–2003), American sinologist Derk Boerrigter (born 1986), Dutch footballer Derk Cheetwood (born 1973), American actor Derk Droze (born 1972), American soccer player Derk Jan Eppink (born 1958), Dutch journalist and politician Derk Rijkens (born 1975), Dutch cricketer Derk Sauer (1952–2025), Dutch journalist and media proprietor Derk Gerard Willem Spitzen (1896–1957), Dutch politician Jacob Derk Carel van Heeckeren (1730–1795), Baron of Ruurlo