Karunanidhi ministry may refer to these cabinets headed by Indian politician M. Karunanidhi as chief minister of Tamil Nadu:

First Karunanidhi ministry (1969-1971) Second Karunanidhi ministry (1971–1976) Third Karunanidhi ministry (1989–1991) Fourth Karunanidhi ministry (1996-2001) Fifth Karunanidhi ministry (2006-2011)