Santo Antão, Portuguese for "Saint Anthony", may refer to the following places.
Brazil Vitória de Santo Antão, Pernambuco
Cape Verde Santo Antão, Cape Verde, the northwesternmost island in Cape Verde archipelago
Portugal Santo Antão (Évora), a civil parish in the municipality of Évora Santo Antão do Tojal, a civil parish in the municipality of Loures Santo Antão (Calheta), a civil parish in the municipality of Calheta, São Jorge, Azores