Seydlitz, von Seydlitz or von Seidlitz is a surname of Prussian, Silesian, Thuringian, Saxon and Polish nobility. It may refer to:

People Friedrich Wilhelm von Seydlitz (1721–1773), a Prussian general of the cavalry Józef Seydlitz (1755–1835), a Polish military commander and a colonel of the Polish Army Woldemar von Seidlitz (1850–1922), an art historian Walther von Seydlitz-Kurzbach (1888–1976), a German general

Ships , a 25,000 ton battlecruiser of the Imperial German Navy German cruiser Seydlitz, a heavy World War II cruiser that was never completed , a World War II Vorpostenboot

Other Seidlitz powders, a laxative and digestion regulator named after the town of Sedlec, Czech Republic