Vasilopoulos or Vassilopoulos () is a Greek surname. The feminine form is Vasilopoulou (Βασιλοπούλου). It may refer to:
Balanos Vasilopoulos (1694–1760), Greek scholar, cleric and writer Christos Vasilopoulos (born 1978), Greek actor Christos Vasilopoulos (footballer) (born 1962), Greek professional footballer Dionysios Vasilopoulos (1902–1964), Greek swimmer Fotios Vasilopoulos (born 1986), Greek professional basketball player Panagiotis Vasilopoulos (born 1984), Greek basketball player
See also Alfa-Beta Vassilopoulos, Greek supermarket chain