Papazyan (in Armenian Փափազյան) (in Western Armenian Papazian, Փափազեան) is a surname of Armenian origin.
Notable people with the surname include:
Papazyan Arutyun Papazyan (born 1954), Armenian pianist Vahram Papazyan (athlete) (1892–1986), one of two athletes who represented Turkey in the 1912 Summer Olympics
Papazian Aghavni Papazian (floruit 1879), Ottoman Armenian actress Arousyak Papazian (1841–1907), Ottoman Armenian actress Charlie Papazian, American nuclear engineer and homebrewer Haig Papazian, Lebanese Armenian violinist, member of the Lebanese alternative rock band Mashrou' Leila Marty Papazian, American actor Mary Papazian, American administrator and professor in English Vahan Papazian (1876–1973), Armenian political activist Vahram Papazian (1886–1968), Soviet Armenian actor Vrtanes Papazian (1866–1920), Armenian writer, historian, activist, translator, literary critic and editor