Vandeweghe, Van de Weghe or Vande Weghe (), also spelled Vandewege or Van de Wege, is a Dutch-language surname from Flanders. Notable people with the surname include:
Al Vande Weghe (1916–2002), American swimmer Al Vandeweghe (1920–2014), American football player Bud VanDeWege (born 1958), American basketball coach Charles Vandeweghe (born 1982), Belgian field hockey player CoCo Vandeweghe (born 1991), American tennis player Ernie Vandeweghe (1928–2014), American basketball player and physician Kevin Van De Wege (born 1974), American firefighter and politician Kiki VanDeWeghe (born 1958), American basketball executive, former player and coach Loïc Vandeweghe (born 1983), Belgian field hockey player Marc Van De Weghe (born 1964), Belgian swimmer Tauna Vandeweghe (born 1960), American swimmer