Van Niekerk is an Afrikaans surname. Notable people with the surname include:
Barend van Niekerk (1939–1981), South African lawyer and academic Dane van Niekerk (born 1993), South African cricketer Dennis van Niekerk (born 1984), South African cyclist Dewald van Niekerk (born 1997), South African squash player Janro van Niekerk (born 1982), South African rugby union player Joe van Niekerk (born 1980), South African rugby union player Kraai van Niekerk (born 1938), South African politician Lara van Niekerk (born 2003), South African swimmer Marlene van Niekerk (born 1954), South African writer Martin van Niekerk (born 1989), Namibian cricketer Wayde van Niekerk (born 1992), South African sprinter