Ofosu is an Akan surname with Ashanti origins. Notable people with the surname include:
Emmanuel Ofosu Yeboah (born 1977), Ghanaian athlete and activist Lawrence Henry Yaw Ofosu-Appiah (1920–1990), Ghanaian academic Michael Ofosu-Appiah (born 1983), Ghanaian footballer Phil Ofosu-Ayeh (born 1991), German-Ghanaian footballer Reagy Ofosu (born 1991), German footballer Samuel Ofosu-Ampofo, Ghanaian politician