Wirths is a German surname. Notable people with the surname include:
Carl Wirths (1897–1955), German politician Eduard Wirths (1909–1945), Nazi German SS doctor at Auschwitz concentration camp during World War II Günter Wirths (1911–2005), German chemist Harold J. Wirths, American politician from New Jersey Wallace R. Wirths (1921–2002), American business executive, author, newspaper columnist and radio commentator, and benefactor of Upsala College
See also Wirth, a surname