The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938, by the Swiss chemist Albert Hofmann in the Sandoz laboratories in Basel, Switzerland.Albert Hofmann; translated from the original German (LSD Ganz Persönlich) by J. Ott. MAPS-Volume 6, Number 69, Summer 1969 It was not until five years later on April 16, 1943, that the psychedelic properties were found.
Discovery Albert Hofmann, born in Switzerland, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel, as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of Scilla glycosides (an active principle of Mediterranean squill). While researching lysergic acid derivatives, Hofmann first synthesized LSD on November 16, 1938. The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic). It was set aside for five years, until April 16, 1943, when Hofmann decided to take a second look at it. While re-synthesizing LSD, he accidentally absorbed a small amount of the drug and discovered its powerful effects. He described what he felt as being:
Bicycle Day
On April 19, 1943, Hofmann ingested 0.25 milligrams (250 micrograms) of the substance, which he estimated to be a small dose, but is actually about 10 times the minimum amount that produces a psychedelic effect. Between one and two hours later, Hofmann experienced slow and gradual changes in his perception. He asked his laboratory assistant to escort him home. As was customary in Basel, they made the journey by bicycle. On the way, Hofmann's condition rapidly deteriorated as he struggled with feelings of anxiety, alternating in his beliefs that the next-door neighbor was a malevolent witch, that he was going insane, and that the LSD had poisoned him. When the house doctor arrived, however, he could detect no physical abnormalities, save for a pair of widely dilated pupils. Hofmann was reassured, and soon his terror began to give way to a sense of good fortune and enjoyment, as he later wrote:
The events of this first LSD trip, now known as "Bicycle Day", after the bicycle ride home, proved to Hofmann that he had indeed made a significant discovery: a psychoactive substance with extraordinary potency, capable of causing significant shifts of consciousness in incredibly low doses. (The term trip was first coined by US Army scientists during the 1950s when they were experimenting with LSD.) Hofmann foresaw the drug as a powerful psychiatric tool; because of its intense and introspective nature, he could not imagine anyone using it recreationally.
Bicycle Day is an informal celebration on April 19th of the anniversary of this first LSD trip, and the psychedelic revolution in general. It is sometimes celebrated by riding a bike on psychedelics and/or in a parade, and often with psychedelic-themed festivities. The celebration of Bicycle Day originated in DeKalb, Illinois, in 1985, when Thomas B. Roberts, then a professor at Northern Illinois University, invented the name "Bicycle Day" when he founded the first celebration at his home. Several years later, he sent an announcement made by one of his students to friends and Internet lists, thus propagating the idea and the celebration. His original intent was to commemorate Hofmann's original, accidental exposure on April 16, but that date fell midweek and was not a good time for the party, so he chose the 19th to honor Hofmann's first intentional exposure.
Publication LSD was first published in the scientific literature by Hofmann and his colleague psychiatrist Werner Stoll in 1943 and the hallucinogenic effects of LSD were first published by Stoll in 1947.
Psychiatric use
Sandoz manufactured LSD for research use, and provided ampules to qualified researchers under the trade-name Delysid in 1947.
LSD was brought to the attention of the United States in 1949 by Sandoz Laboratories because they believed LSD might have clinical applications.
Throughout the 1950s, mainstream media reported on research into LSD and its growing use in psychiatry, and undergraduate psychology students taking LSD as part of their education described the effects of the drug. Time magazine published six positive reports on LSD between 1954 and 1959.
LSD was originally perceived as a psychotomimetic capable of producing model psychosis. By the mid-1950s, LSD research was being conducted in major American medical centers, where researchers used LSD as a means of temporarily replicating the effects of mental illness. One of the leading authorities on LSD during the 1950s in the United States was the psychoanalyst Sidney Cohen. Cohen first took the drug on October 12, 1955, and expected to have an unpleasant trip, but was surprised when he experienced "no confused, disoriented delirium." He reported that the "problems and strivings, the worries and frustrations of everyday life vanished; in their place was a majestic, sunlit, heavenly inner quietude." Cohen immediately began his own experiments with LSD with the help of Aldous Huxley whom he had met in 1955. In 1957, with the help of psychologist Betty Eisner, Cohen began experimenting on whether or not LSD might have a helpful effect in facilitating psychotherapy, curing alcoholism, and enhancing creativity. Between 1957 and 1958, they treated 22 patients who had minor personality disorders. LSD was also given to artists in order to track their mental deterioration, but Huxley believed LSD might enhance their creativity. Between 1958 and 1962, psychiatrist Oscar Janiger tested LSD on more than 100 painters, writers, and composers.
In one study in the late 1950s, Humphry Osmond gave LSD to alcoholics in Alcoholics Anonymous who had failed to quit drinking. After one year, around 50% of the study group had not had a drink—a success rate that has never been duplicated by any other means. Bill Wilson, the founder of Alcoholics Anonymous, participated in medically supervised experiments on the effects of LSD on alcoholism and believed LSD could be used to cure alcoholics.
In the United Kingdom the use of LSD was pioneered by Ronald A. Sandison in 1952, at Powick Hospital, Worcestershire. A special LSD unit was set up in 1958. After Sandison left the hospital in 1964, medical superintendent Arthur Spencer took over and continued the clinical use of the drug until it was withdrawn from production by Sandoz in 1965. In all, 683 patients were treated with LSD in 13,785 separate sessions at Powick, but Spencer was the last member of the medical staff to use it.
From the late 1940s through the mid-1970s, extensive research and testing was conducted on LSD. During a 15-year period beginning in 1950, research on LSD and other hallucinogens generated over 1,000 scientific papers, several dozen books, and six international conferences. Overall, LSD was prescribed as treatment to over 40,000 patients. Film star Cary Grant was one of many men during the 1950s and 1960s who were given LSD in concert with psychotherapy. Many psychiatrists began taking the drug recreationally and sharing it with friends. Leary's experiments (see Timothy Leary below) spread LSD usage to a much wider segment of the general populace.
Sandoz halted LSD production in August 1965 after growing governmental protests at its proliferation among the general populace. The National Institute of Mental Health in the United States distributed LSD on a limited basis for scientific research. Scientific study of LSD largely ceased by about 1980 as research funding declined, and governments became wary of permitting such research, fearing that the results of the research might encourage illicit LSD use. By the end of the 20th century, there were few authorized researchers left, and their efforts were mostly directed towards establishing approved protocols for further work with LSD in easing the suffering of the dying and with drug addicts and alcoholics.
A 2014 study showed evidence that LSD can have therapeutic benefits in treating anxiety associated with life-threatening diseases. Rick Doblin, an American drug researcher, described the work as "a proof of concept" that he hoped would "break these substances out of the mold of the counterculture and bring them back to the lab as part of a psychedelic renaissance."
Resistance and prohibition
By the mid-1960s the backlash against the use of LSD and its perceived corrosive effects on cultural values resulted in governmental action to restrict the availability of the drug by making use of it illegal. LSD was declared a "Schedule I" substance, legally designating that the drug has a "high potential for abuse" and is without any "currently accepted medical use in treatment." LSD was removed from legal circulation. The United States Drug Enforcement Administration claimed:
The governors of Nevada and California each signed bills into law on May 30, 1966, that make them the first two American states to outlaw the manufacture, sale, and possession of the drug. The law went into effect immediately in Nevada, and on October 6, 1966, in California. Other U.S. states and many other countries soon followed with similar bans.
Influential individuals Aldous Huxley Renowned British intellectual Aldous Huxley was one of the most important figures in the early history of LSD. He was a figure of high repute in the world of letters and had become internationally famous through his novels Crome Yellow, Antic Hay and his dystopian novel Brave New World. His experiments with psychedelic drugs (initially mescaline) and his descriptions of them in his writings did much to spread awareness of psychedelic drugs to the general public and arguably helped to glamorize their recreational use, although Huxley himself treated them very seriously.
Huxley was introduced to psychedelic drugs in 1953 by a friend, psychiatrist Humphry Osmond. Osmond had become interested in hallucinogens and their relationship to mental illness in the 1940s. During the 1950s, he completed extensive studies of a number of drugs, including mescaline and LSD. As noted above, Osmond had some remarkable success in treating alcoholics with LSD.
In May 1953 Osmond gave Huxley his first dose of mescaline at the Huxley home. In 1954 Huxley recorded his experiences in the landmark book The Doors of Perception; the title was drawn from a quotation by British artist and poet William Blake. Huxley tried LSD for the first time in 1955, obtained from "Captain" Al Hubbard.
Alfred Hubbard
Alfred Matthew Hubbard is reputed to have introduced more than 6,000 people to LSD, including scientists, politicians, intelligence officials, diplomats, and church figures. He became known as the original "Captain Trips", travelling about with a leather case containing pharmaceutically pure LSD, mescaline, and psilocybin. He became a "freelance" apostle for LSD in the early 1950s after supposedly receiving an angelic vision telling him that something important to the future of mankind would soon be coming. When he read about LSD the next year, he immediately sought and acquired LSD, which he tried for himself in 1951.