Papantoniou () is a Greek surname. According to Greek naming conventions, these people are descendant of a priest named Antonis. Notable people with the surname include:
Epameinondas Papantoniou (born 1990), Greek professional basketball player Evelina Papantoniou (born 1979), Greek fashion model and actress Giannis Papantoniou (1928–2015), Greek footballer Ioanna Papantoniou (1936–2026), Greek author, scenic designer, costume designer and folklorist Nondas Papantoniou (born 1990), Greek basketball player Yiannos Papantoniou (born 1949), Greek politician Zacharias Papantoniou (1877–1940), Greek writer and journalist
See also Antoniou