Vetlesen is a Norwegian patronymic surname, literally meaning "son of Vetle". It may refer to:
Arne Johan Vetlesen (born 1960), Norwegian philosopher G. Unger Vetlesen (1889–1959), Norwegian shipbuilder Hugo Vetlesen (born 2000), Norwegian footballer Ingrid Vetlesen (born 1981), Norwegian singer Leif Vetlesen (1921–2003), Norwegian sailor and politician Vesla Vetlesen (born 1930), Norwegian weaver, trade unionist, writer and politician, and second wife of Leif Vetlesen
See also Vetlesen Prize, Columbia University award