McGuffie is a surname. Notable people with the surname include:
Bill McGuffie (1927–1987), British composer Craig McGuffie (born 1997), Scottish footballer Louis McGuffie (1893–1918), Scottish World War I Victoria Cross recipient Ryan McGuffie (born 1980), Scottish footballer Sam McGuffie (born 1989), American football player Sheila McGuffie (1911–2007), English aeronautical engineer Walter McGuffie (1916–1996), British Olympic wrestler Will McGuffie (born 2000), English footballer