Zamfirescu is a Romanian surname. Notable people with the surname include:
Duiliu Zamfirescu (1858–1922), novelist, poet, short story writer, lawyer, nationalist politician, journalist, diplomat Florin Zamfirescu (born 1949), theatre and film actor and director George Mihail Zamfirescu (1898–1939), theatre director and playwright Elisa Leonida Zamfirescu (1887–1973), an early woman engineer Mihail Zamphirescu (1838–1878), poet
See also Zamfir Zamfirești (disambiguation)