21st Century Girl may refer to:

21st Century Girl (album), by Brazzaville, or the title song, 2008 "21st Century Girl" (song), by Willow Smith, 2011 "21st Century Girl", a song by Joey Ramone from the 2012 album ...Ya Know? , a 2019 anthology of short films produced by Yūki Yamato

See also 21st Century Girls, a 1990s British band "21st Century Girls", a song by BTS from the 2016 album Wings