Spofford may refer to: Spofford, New Hampshire Spofford Lake Spofford Juvenile Center, New York City Spofford, Texas Spofford (play), a 1967 play People with the surname Ainsworth Rand Spofford (1825–1908), Librarian of Congress, 1864–1897 Charles Spofford (1902–1991), lawyer Edward Spofford, American professor of literature Harriet Elizabeth Prescott Spofford (1835–1921), American writer Henry M. Spofford (1821–1880), 19th-century Louisiana politician Janice Spofford (1925–2018), American biologist and geneticist Sally Hoyt Spofford (1914–2002), American ornithologist William B. Spofford (1921–2013), Episcopal bishop
See also Otis Spofford, a children's novel Spafford (disambiguation) Spofforth, North Yorkshire, England, UK Spofforth Castle