ARMCX5 is an armadillo repeat–containing protein that is encoded by the X-linked ARMCX5 gene. It is conserved only in Eutheria, a specific group of placental mammals, but no further back in evolutionary time. ARMCX5 contains 3 ARM-like repeats, DUF364, and ARM-type fold.
Features Accession Number NC_0002.10Aliases FLJ12969, FLJ13382, and RP4-769N13.3Chromosomal locationXq22.1-q22.3Gene size4991 base pairsmRNA size2924 base pairsProtein size588 amino acids
Splice Variants ARMCX5 has 6 splice variants.
Splice isoform/transcript variant mRNA sequence length Accession number12924NM_001168479.122695NM_022838.332808NM_001168478.142918NM_001168480.152805NM_001168485.162707NM_001168482.1
ORTHOLOGS ARMCX5 has ten orthologs. Ortholog genus name Common name Accession number Sequence length Sequence identity Sequence similarityPongo abelliOrangatuanXP_002831961.154797.1%99%Macaca mulataRhesus monkeyEHH30927.155895.3%97%Macaca fascicularisCrab eating macaqueEHH61076.155895%97%Callithrix JacchusCommon marmosetXP_002763850.156889.4%93%Equus caballusHorseNC009175.260980%85%Canis lupus familiarisdogXP_538116.260879%85%Sus scrofaCommon pigXP_003135327.273278%85%Oryctolagus cuniculusCommon rabbitXP_00272091.154776.8%85%Rattus norvegicusCommon ratXP_001499348.256761.1%76%Mus musculusMouseNP_001009575.260657%71%
Paralogs ARMCX5 has 8 paralogs listed by genecards: GPRASP2, ARMCX1, BHLHB9, ARMCX2, GPRASP1, ARMCX6, ARMCX10, and ARMCX3.
Function Proteins containing this ARMCX5 domain interact with numerous other proteins. Through these interactions, they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation f circadian rhythm and lysosomal sorting of G-protein coupled receptors.
Because DUF364 contains a PLP-dependent transferase-like fold, the genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis.
Expression ARMCX5 is a highly ubiquitously expressed gene that has shown expression in many tissues.
Body Site Transcripts per million Gene EST/Total EST in poolBrain2528/1092524Bone marrow824/48711Mouth604/66139Vascular583/51637Spleen563/53365Mammary gland528/151228Esophagus491/20152Larynx421/23489Trachea382/51769Muscle374/106323Testes3311/327305
References