Santoni is a surname. Notable people with the surname include:
Dante Santoni (born 1960), American politician from Pennsylvania Elisa Santoni (born 1987), Italian rhythmic gymnast Félix Santoni, Puerto Rican politician François Santoni, suspected of being one of the leaders of Armata Corsa, a defunct separatist terrorist organization in Corsica Joël Santoni (born 1943), French film director and screenwriter Michael Santoni Jr. (born 1964), wrestler known as Big Guido Nicola Santoni (born 1979), Italian football player Reni Santoni (born 1939), American actor