Moussaieff is a Bukharian Jewish surname, a French-language spelling of the patronymic surname Musayev derived from the Arabic name Musa. Notable people with the surname include:
Dorrit Moussaieff (born 1950), Israeli jewellery designer, First Lady of Iceland Jeffrey Moussaieff Masson (born 1941), American author Shlomo Moussaieff (businessman) (1925–2015), Israeli-born millionaire in London Shlomo Moussaieff (rabbi) (1852–1922), rabbi and gemstone trader from Uzbekistan, and founder of the Bukharim neighborhood of Jerusalem See also
Moussaieff Red Diamond, a 5.11-carat fancy red diamond