Guthrie is an unincorporated community in Kanawha County, West Virginia, United States, near Twomile Creek. Guthrie is named after James Guthrie who settled in the area around 1798.Sissonville, A Time To Remember, p. 86 In 1800 he married Elizabeth Casdorph.Elk River Communities in Kanawha County: A Continuing History. (1993). United States: The Society. p. 4The Casdorphs: from Hamburg to the Kanawha Valley, West Virginia, 1625-1995, a documentary James and Elizabeth had brothers serve in the War of 1812.History of Kanawha County, by George W. Atkinson (Charleston, 1876)

They had nine children: Henson, Elijah, Mary, Nancy, Martha, Sarah, James, John, and Julia Ann. Sarah was the grandmother of Tampa insurance agent Norris W. Hensley."Florida, Funeral Home Records, 1887-1971", FamilySearch (21 November 2023), Mordicie Hensley, 1923. James Guthrie's second wife was Judith Hensley.

The Bonham Dairy was in Guthrie.

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