Rennae Stubbs and Jared Palmer were the defending champions but only Stubbs competed that year with Todd Woodbridge.
Stubbs and Woodbridge lost in the semifinals to Barbara Schett and Joshua Eagle.
Corina Morariu and Ellis Ferreira won in the final 6–1, 6–3 against Schett and Eagle.
This was the first Australian Open to replace the final tie-break set for a super tie-break or a "champions tie-break" to define the match in the mixed doubles category.
Seeds Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.
Draw
Final
Top half
Bottom half
External links 2001 Australian Open Mixed Doubles Draw 2001 Australian Open – Doubles draws and results at the International Tennis Federation