Thruston is a surname and may refer to:

Buckner Thruston (1763–1845), U.S. Senator and federal judge, father of Charles Mynn (Union general) Charles Mynn Thruston (colonel) (1738–1812), colonel of a Continental Army regiment, father of Buckner Charles Mynn Thruston (1798–1873), brigadier general in the Union Army Gates P. Thruston (1835–1912), American lawyer, businessman and collector Lucy Meacham Thruston (1862–1938), American writer of historical novels Malachi Thruston, Colonial Virginia court clerk, planter and burgess Thruston may refer to people with the first or middle name Thruston:

S. Thruston Ballard (1855–1926), lieutenant governor of Kentucky Thruston Ballard Morton (1907–1982), Congressman from Kentucky

Military Thruston's Additional Continental Regiment, an American infantry unit in the American Revolutionary War

Similar spellings Threston Thurston (disambiguation) Thruxton (disambiguation)