Seán or Sean Burke may refer to:

Seán Burke (Gaelic footballer) (born 1970), Irish retired Gaelic footballer Seán Burke (hurler), Irish hurler Sean Burke (born 1967), Canadian former professional ice hockey goaltender Sean Burke (baseball), baseball player Seán Burke (author), literary theorist and novelist Sean M. Burke, author, linguist and programmer Sean Burke, English musician and former member of Tubeway Army Shawn Burke, of Hamilton Tiger-Cats