John Upton may refer to:
Politicians John Upton (died c.1453), MP for Warwick John Upton, 1st Viscount Templetown (1771–1846), British Member of Parliament for Bury St Edmunds John Upton (died 1687) (1639–1687), British Member of Parliament for Dartmouth John Upton (born 1718), Member of Parliament for Westmorland John Upton (mayor), Mayor of Auckland City 1889–1891 John Upton (Irish politician), Member of the Parliament of Ireland for County Antrim 1725–1741 John Upton (died 1641) (1590–1641), British Member of Parliament for Dartmouth John Upton, MP for Haverfordwest 1656–1660
Others Sir John Upton (died 1551), one of the last leaders of the English Langue of the Knights of St. John John Upton (civil engineer) (1774–1851), English civil engineer and contractor working in England and Russia John Upton (Spenser editor) (1707–1760), early editor of Edmund Spenser John Upton, president of the Baptist World Alliance John A. Upton (born 1850), painter active in South Australia John Charles Upton Jr. (?–2013), American documentary film maker