D'Aquino is an Italian surname and a variant of Aquino. It may refer to:
Iva Toguri D'Aquino (1916–2006), American who participated in Radio Tokyo English-language propaganda broadcasts during World War II John D'Aquino (born 1958), Canadian-American actor, played Lt. Benjamin Krieg in the NBC TV series seaQuest DSV Matt D'Aquino (born 1985), Australian Judoka who has represented Judo at the 2008 Beijing Olympic Games and four World Championships Raffaele D'Aquino (born 1903), Italian professional football player
See also D'Aquino family, Italian noble family San Mango d'Aquino, town and comune in the province of Catanzaro, in the Calabria region of southern Italy