Jefferys is a surname. Notable people with the name include:
Charles Jefferys (1807–1865), English music publisher and composer Charles William Jefferys (1869–1951), Canadian historical illustrator Eddie Jefferys (fl. 2010s), English music producer Edward Jefferys (1936–1998), South African sprinter Helen Jeffreys Bakhtiar (1905–1973; née Helen Woodsen Jeffreys), American nurse, civil servant John Jefferys (fl. mid-18th century), British game designer John Jefferys (clockmaker) (1701–1754), English horologist Margot Jefferys (1916–1999), British medical sociologist Steve Jefferys, Australian horse trainer, appeared in the 2000 Sydney Olympics Opening Ceremony Thomas Jefferys (c. 1719–1771), English cartographer William H. Jefferys (born 1940), American astronomer
See also Jefferys Allen (1760–1844), British politician, MP for Bridgwater Jefferies