Wexelsen is a surname. Notable people with the surname include:
Håkon Wexelsen (1898–1979), Norwegian plant geneticist Håkon Wexelsen Freihow (born 1927), Norwegian diplomat Halvdan Wexelsen Freihow (1883–1965), Norwegian priest and culturist Marie Wexelsen (1832–1911), Norwegian poet, children's writer and novelist Vilhelm Andreas Wexelsen (1849–1909), Norwegian bishop and politician for the Liberal Party