William Guise was an orientalist.
William Guise may also refer to:
Sir William Guise, 5th Baronet (1737–1783), MP for Gloucestershire Sir William Vernon Guise, 4th Baronet (1816–1887), of the Guise baronets Sir William Francis George Guise, 5th Baronet (1851–1920), of the Guise baronets
See also Guise (surname)