This is a list of adrenergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of the neurotransmitter epinephrine (adrenaline).
Receptor ligands α1-adrenergic receptor ligands Agonists
Antagonists
Many tricyclic antidepressants, tetracyclic antidepressants, antipsychotics, ergolines, and some piperazines like buspirone, trazodone, nefazodone, etoperidone, and mepiprazole antagonize α1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
α2-adrenergic receptor ligands Agonists
Antagonists
Many atypical antipsychotics and azapirones like buspirone and gepirone (via metabolite pyrimidinylpiperazine) antagonize α2-adrenergic receptors as well.
β-adrenergic receptor ligands Agonists
Antagonists
Reuptake inhibitors Norepinephrine transporter (NET) inhibitors
Vesicular monoamine transporter (VMAT) inhibitors
Releasing agents
Enzyme inhibitors Anabolism Phenylalanine hydroxylase (PAH) inhibitors
Tyrosine hydroxylase inhibitors
Aromatic L-amino acid decarboxylase (AAAD) inhibitors
Dopamine-beta-hydroxylase (DBH) inhibitors
Phenylethanolamine N-methyltransferase (PNMT) inhibitors
Catabolism Monoamine oxidase (MAO) inhibitors
MAO-B inhibitors also influence norepinephrine/epinephrine levels since they inhibit the breakdown of their precursor dopamine.
Catechol-O-methyl transferase (COMT) inhibitors
Others Precursors
Cofactors
Activity enhancers
Release blockers
Toxins
References