Little Creek may refer to:

Places in the United States Little Creek, Delaware, a town in Kent County Little Creek Hundred, Kent County, an unincorporated subdivision in Delaware Little Creek Hundred, Sussex County, an unincorporated subdivision in Delaware Little Creek, Georgia, an unincorporated community Little Creek Peak, a mountain in Utah Naval Amphibious Base Little Creek, a United States Navy base in Virginia Beach, Virginia

Waterways Little Creek (Gualala River), a tributary of the Gualala River in California Little River (Delaware), also called Little Creek, a tributary of Delaware Bay Little Creek (North Fork River), a stream in Missouri Little Creek (Addition Creek tributary), a stream in Montana Little Creek (New Jersey), a river in Burlington County Little Creek (New York), a tributary of Cayuga Lake Little Creek (Cape Fear River tributary), a stream in Harnett County, North Carolina Little Creek (East Branch Tunkhannock Creek tributary), a creek in Pennsylvania