Grego is a surname. Notable people with the surname include:
Alessandro Grego (born 1969), Italian composer Andrea Grego (1400–1485), Italian Dominican friar and preacher Antun Grego (born 1940), Croatian sailor Bojan Grego (born 1970), Croatian sailor Egidio Grego (1894–1917), Italian aviator Jim Grego (born 1955), American politician João Grego, 15th century Portuguese explorer Joseph Grego (1843–1908), English art collector Laura Grego, American physicist Melania Grego (born 1973), Italian water polo player