Iacobescu () is a Romanian surname, derived from the given name Jacob. Notable people with the name include:
Antonia Iacobescu (born 1989), Romanian singer and model Dumitru Iacobescu (1893–1913), Romanian Symbolist poet George Iacobescu (born 1945), Romanian-British businessman, the chief executive of Canary Wharf Group
See also Iacobeşti (plural form)