CSRP2-binding protein is a protein that in humans is encoded by the KAT14 gene (previously CSRP2BP). This function is part of the ADA2A-containing complex (ATAC), a protein complex that acts as an histone acetyltransferase for the histones H3 and H4. Also called lysine acetyltransferase 14 (KAT14), CSRP2BP itself has weak histone acetyltransferase activity towards H4.
CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described.
References
External links
Further reading