Santa Cruz de la Sierra (Extremaduran: Santa Crus dela Sierra) is a municipality located in the province of Cáceres and autonomous community of Extremadura, Spain. The municipality covers an area of and had a population of 278 people.
Prominent figures Ñuflo de Chaves was born here and founded the city of Santa Cruz de la Sierra, Bolivia, in 1561. See also List of municipalities in Cáceres
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