Cathedral of Our Lady of Guadalupe may refer to:
France Basse-Terre Cathedral (Cathédrale Notre-Dame-de-Guadeloupe de Basse-Terre), Guadeloupe
Mexico Ciudad Juárez Cathedral (Catedral de Nuestra Señora de Guadalupe de Ciudad Juárez), Chihuahua Diocesan Sanctuary of Our Lady of Guadalupe, Zamora, Michoacán Huajuapan de León Cathedral (Catedral de la Virgen de Guadalupe), Oaxaca
Puerto Rico Catedral de Nuestra Señora de Guadalupe, Ponce
United States Cathedral of Our Lady of Guadalupe (Alaska), in Anchorage Cathedral of Our Lady of Guadalupe (Kansas), in Dodge City Cathedral Santuario de Guadalupe (Dallas, Texas)
Uruguay Cathedral of Our Lady of Guadalupe (Canelones)
See also Our Lady of Guadalupe Church (disambiguation)