Pleșca is a surname. Notable people with the surname include:
Aurora Pleșca (born 1963), Romanian rower Nae-Simion Pleșca (born 1955 or 1957), Moldovan politician Răzvan Pleșca (born 1982), Romanian footballer Valeriu Pleșca (born 1958), Moldovan lawyer and politician
See also Plesca, a village in the Cizer commune in Sălaj County, Romania