Maria Sharapova defeated Jelena Janković in the final, 4–6, 7–6(7–3), 6–3 to win the women's singles tennis title at the 2011 Cincinnati Masters.

Kim Clijsters was the reigning champion, but withdrew due to an abdominal injury.

Seeds The top eight seeds received a bye into the second round.

Qualifying

Main draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

References Main Draw