Wyllis is both a surname and a given name. Notable people with the name include:
People with the surname Francis Wyllis (died 1597), English academic administrator and dean George Wyllis (1590–1645), American governor Mason Wyllis (2003-Present), Former Collegiate American football player at Concordia University Ann Arbor (MI). Mason is currently a College Football coach at University of Minnesota, Twin Cities.
People with the given name Wyllis Cooper (1899–1955), American writer and producer Edward Wyllis Scripps (1854–1926), American newspaper publisher
See also Willis (disambiguation)