Perine is a surname. Notable people with the name include:
Edward Martineau Perine (1809–1905), American merchant and planter George Edward Perine (1837–1885), American artist, engraver, and publisher Kelly Perine (born 1969), American television actor La'Mical Perine (born 1998), American football player Samaje Perine (born 1995), American football player and running back for the Cincinnati Bengals
See also Perrine (disambiguation) Perin (disambiguation) Billiou-Stillwell-Perine House, the oldest extant house on Staten Island, New York