Colt 45 may refer to:
Firearms .45 ACP cartridge .45 Colt cartridge Colt Single Action Army, a revolver produced by Colt's Manufacturing Company M1911 pistol, a semi-automatic pistol produced by Colt's Manufacturing Company
Arts, entertainment, and media Colt .45 (1950 film), a Randolph Scott Western Colt 45 (2014 film), a French thriller Colt .45 (TV series), a Western television series "Colt 45" (song) or "2 Zig Zags", alternate names for "Crazy Rap", a 2000 single by Afroman Colts Drum and Bugle Corps, previously named the Colt .45 Drum and Bugle Corps
Sports Colt 45 (basketball), a Philippine Basketball League team Colt 45, the finishing maneuver of professional wrestlers Colt Cabana and Colten Gunn Houston Colt .45s, a baseball team that was renamed the Houston Astros
Other uses Colt 45 (malt liquor), an American alcoholic beverage brewed by the Pabst Brewing Company
See also .45 caliber