Semprun or Semprún may refer to:
Carlos Semprún (1926-2009), Spanish writer Jaime Semprún (1947–2010), French essayist Jorge Semprún (1923–2011), Spanish writer and politician José Alejandro Semprún (born 1973), Venezuelan long-distance runners Pablo Semprún (born 1964), Spanish tennis and padel tennis player Patricia Carola Velásquez Semprún (born 1971), Venezuelan actress and model Manuel Semprún y Pombo (1868–1929), Spanish lawyer