SMEP may refer to:
Plant matrix metalloproteinase, also referred as SMEP1 Standard model of elementary particles Supervisor mode execution protection, a security feature of some Intel CPUs
Organisations SMEP Microfinance Bank Paris Evangelical Missionary Society (French: ) Sony Music Entertainment Philippines, a defunct company Sony Music Entertainment Poland Society of Metallurgical Engineers of the Philippines, an engineering society Society of Mechanical Engineers of Pakistan; See Ghulam Ishaq Khan Institute of Engineering Sciences and Technology Society of Multivariate Experimental Psychology