CAFC may refer to:
Canadian Anti-Fraud Centre Commission for Assistance to a Free Cuba, U.S. government organization established in 2003 to formulate policies for a democratic transition in Cuba United States Court of Appeals for the Federal Circuit California Fire Safe Council Cobblestone area forming cells in stem cell research Corporate-average fuel consumption
Association football clubs: Charlton Athletic F.C. Crewe Alexandra F.C. Cadbury Athletic F.C. Carshalton Athletic F.C. Consett A.F.C. Cork Alberts F.C. Cork Athletic F.C. Crown Alexandra F.C. Croydon Athletic F.C. Curzon Ashton F.C.