Masiello is a surname originating in Italy. Notable people with the surname include:
Andrea Masiello (born 1986), Italian soccer player Anthony Masiello, Buffalo, New York, politician Caroline A. Masiello, American biogeochemist Luciano Masiello (born 1952), Italian-born English and Irish soccer player Salvatore Masiello (born 1982), Italian soccer player Wendy M. Masiello, United States Air Force officer