USS Potomac or USNS Potomac may refer to one of these United States Navy ships:
, a frigate in commission from 1831 to 1877 , a whaler purchased in 1861 and sunk as part of the "Stone Fleet" in 1862 , a tug in commission from 1898 to 1922 , a presidential yacht in service from 1936 to 1945 , an oiler in service from 1957 until destroyed in a fire in 1961 , an oiler in service from 1976 to 1983 USS Potomac (SSN-814), an attack submarine announced in 2025