Nessler or Neßler is a German surname. Notable people with the surname include:
Brad Nessler (born 1956), American sportscaster Julius Neßler (1827–1905), German chemist Martha Nessler Hayden, (born 1936), American painter, maiden name Nessler. Karl Nessler (1872–1951), German-born American inventor Viktor Nessler (1841–1890), Alsatian composer
See also Nessler ball, ammunition round made for the late smoothbore musket Nessler cylinder, laboratory tubes with a fixed volume Nesler