Quattlebaum is a surname. Notable people with the surname include:
A. Marvin Quattlebaum Jr., United States federal judge Cephas Perry Quattlebaum C.P. Quattlebaum Office, a historic law office building located at Conway in Horry County, South Carolina C.P. Quattlebaum House, a historic home located at Conway in Horry County, South Carolina Paul Quattlebaum House, a historic home located at Conway in Horry County, South Carolina Doug Quattlebaum (1929–1996), American blues guitarist, singer and songwriter Robert Quattlebaum, a developer of animation software