M52, M/52 or M-52 may refer to:

Military M/52 (rifle) M52 rifle grenade M52 self-propelled howitzer, a 1950s US 105 mm artillery MEMS M-52/60, a submachine gun Macchi M.52, a 1920s Italian racing seaplane Miles M.52, a 1942 British supersonic jet project Myasishchev M-52, the second prototype of a Soviet supersonic bomber

Roads and transportation M52, The North/South Metroline in Amsterdam M52 (Cape Town), a Metropolitan Route in Cape Town, South Africa M52 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa M-52 (Michigan highway) M52 highway (Russia) M52, a Metrobus route in Sydney, Australia

Science and technology BMW M52, a 1994 automobile piston engine Messier 52, an open star cluster in the constellation Cassiopeia Samsung Galaxy M52 5G, an Android smartphone by Samsung Electronics.