Afonin () is a Russian surname derived from Afonya, a short form of the name Afanasy. The surname literally means Afonya's. It may refer to:
Mikhail Afonin (1957–2025), Russian football coach Vadim Afonin (born 1987), Uzbek-Russian footballer Valentin Afonin (1939–2021), Soviet footballer Vasily Afonin (1919–1996), Soviet military aviator Vyacheslav Afonin (born 1978), Russian football coach Yury Afonin (born 1977), Russian politician